Twist collar counter-clockwise to unlock; Pull collar up to reveal empty refill; Remove empty refill and replace; Return collar onto glass bottle and twist clockwise to lock; Apply to clean skin morning and night. Avoid eye area; To remove cap, first twist collar clockwise to ensure it is locked. Then open by pulling cap directly upward; Multiple signs of aging; Loss of firmness, tone; Even skintone; Radiance; Dermatologist-tested; Ophthalmologist-tested; Won't cause breakouts, won't clog pores (non-acnegenic)